21 Conditions

What Does Hyperbaric Therapy Treat?

Evidence-based guides for every condition treated with HBOT — from FDA-approved indications to emerging research. Each page includes protocols, recommended chambers, and citations to peer-reviewed studies.

FDA-Approved

FDA-Approved Indications

These conditions are among the 14 FDA-approved indications for HBOT. Insurance coverage is typically available with physician prescription in accredited facilities.

Off-Label & Emerging Uses

These conditions are not FDA-approved for HBOT but have varying levels of clinical research supporting their use. Insurance typically does not cover these applications.

Anti-Aging & Longevity

From telomere lengthening to Bryan Johnson's biomarker protocol — the emerging science of pressurized oxygen for aging.

2.0 ATA·60 sessions·emerging evidence

Athletic Recovery & Sports Performance

From NFL recovery rooms to Bryan Johnson's longevity protocol — how elite athletes use HBOT for performance and recovery.

1.5–2.0 ATA·20–40 sessions (or ongoing maintenance)·moderate evidence

Autism Spectrum Disorder

A balanced assessment of the evidence, what families report, and what the research actually shows.

1.3–1.5 ATA·40 sessions·limited evidence

COVID-19 (Acute Hypoxia)

Emergency HBOT protocols during the COVID pandemic showed reduced ventilator need and ICU mortality. This is distinct from long COVID — a separate indication.

2.0–2.4 ATA (acute hypoxia); 1.5 ATA (subacute)·5–10 sessions·moderate evidence

Cerebral Palsy

The most-studied pediatric HBOT indication — with a landmark Lancet RCT that produced surprising results and ongoing scientific debate.

1.3–1.75 ATA·40 sessions·emerging evidence

Chronic Pain & Fibromyalgia

From fibromyalgia to CRPS — what the research says about HBOT for conditions where standard pain management falls short.

2.0 ATA·40 sessions·moderate evidence

Long COVID

What the research says, which protocols show results, and which chambers meet the clinical threshold.

2.0 ATA (minimum 1.5 ATA)·40–60 sessions·moderate evidence

Lyme Disease

An honest look at the evidence, what the Lyme community reports, and what pressure levels matter.

2.0–2.4 ATA·20–40 sessions·limited evidence

Migraine & Cluster Headaches

100% oxygen is an established emergency treatment for cluster headache. HBOT adds pressure — with emerging evidence for chronic migraine prevention.

1.0–1.5 ATA·5–10 sessions (acute cluster abort); 20–40 sessions (preventive migraine)·emerging evidence

Multiple Sclerosis (MS)

MS-specific HBOT research dates to 1983. Cochrane review found inconclusive disease progression evidence — but symptom relief (fatigue, bladder, spasticity) is better documented.

1.75–2.0 ATA·20 initial sessions + maintenance·limited evidence

PTSD

Military-funded research, Israeli Defense Forces studies, and what the evidence says about HBOT for post-traumatic stress.

1.5–2.0 ATA·40–60 sessions·moderate evidence

Peripheral Artery Disease (PAD)

Medicare covers HBOT for diabetic lower extremity wounds. Evidence shows meaningful amputation risk reduction — with angiogenesis as the key mechanism.

2.0–2.4 ATA·20–40 sessions·moderate evidence

Post-Concussion Syndrome

Multiple RCTs show cognitive, sleep, and headache improvements in mTBI patients — with ongoing $28M veterans trial at USF.

1.5 ATA·40 sessions·moderate evidence

Post-Surgical Recovery

Accelerating healing, reducing complications, and getting back to normal faster after surgery.

1.5–2.0 ATA·10–20 sessions·moderate evidence

Stroke Recovery

Research on reactivating dormant brain tissue and neuroplasticity after stroke — even years after the event.

2.0 ATA·40–60 sessions·moderate evidence

Traumatic Brain Injury (TBI)

From concussions to severe TBI — what the clinical evidence says about HBOT for brain recovery.

1.5–2.0 ATA·40–80 sessions·moderate evidence

Not sure which chamber you need?

Our buyer's guide walks you through pressure, chamber type, FDA clearance, and cost.